NAME: Sandip K. Basu, Ph.D.

EDUCATION:

Undergraduate:

• 1994-1998; Palli Siksha Bhavana (Institute of Agriculture), Visva Bharati, Santiniketan, India; Bachelor of Science, Agriculture (Hons.). Graduation: July 2008

Masters:

• 1999-2001; CCH Haryana Agricultural University, Hisar, India; Master of Science, Biotechnology and Molecular Biology. Graduation: September 2021

Graduate School:

• 2001-2006; International Center for Genetic Engineering and Biotechnology and Jawaharlal Nehru University, New Delhi, India; Doctor of Philosophy, Immunology. Graduation: March 2006

Postgraduate Training:

• 2006-2011; National Cancer Institute-Frederick, NIH, Frederick, Maryland; Visiting Fellow, Tumor suppression mechanisms in oncogenic RAS mediated cancers.

• 2013-2014; Columbia University Medical Center, New York; Postdoctoral Research Scientist, Mouse genetics to understand bone physiology and degenerative diseases

HONORS/AWARDS:

Undergraduate:

• 1998; University Gold Medal for highest GPA; Visva Bharati, Santiniketan, India

• 1995-1998; Merit Scholarship; Palli Siksha Bhavana (Institute of Agriculture), Visva Bharati, Santiniketan, India

• 1996; Tapan Memorial Award for Academic Excellence; Palli Siksha Bhavana (Institute of Agriculture), Visva Bharati, Santiniketan, India

Masters:

• 1999-2001; Monsanto Biotechnology Fellowship, Monsanto India Ltd.

• 1999; Merit Scholarship; CCH Haryana Agricultural University, Hisar, India

Graduate School:

• 2003-2006; Senior Research Fellowship; Council of Scientific and Industrial Research, India

• 2001-2003; Junior Research Fellowship; Council of Scientific and Industrial Research, India

• 2002; Finalist; 2^nd Winter School of Immunology; Indian Immunology Society, Goa, India

Postgraduate Training:

• 2006-2011; Visiting Research Fellowship; National Institute of Health, Bethesda, Maryland

• 2010; Travel Award for best oral presentation; NCI Center for Cancer Research - Fellow and Young Investigators Colloquium

SOCIETY MEMBERSHIPS:

• 2002- present; Indian Immunology Society (IIS)

• 2021-present; Association for Research in Vision and Ophthalmology (ARVO)

ACADEMIC APPOINTMENTS:

• 09/2019- present; Research Instructor, University of Tennessee Health Science Center, College of Medicine, Department of Ophthalmology, Memphis, Tennessee

• 02/2014-02/2018; Research Fellow (FTE), Mouse Cancer Genetics Program, National Cancer Institute-Frederick, NIH, Frederick, Maryland

OTHER ACADEMIC APPOINTMENTS:

• 02/2018-07/2019; Research Volunteer, Mouse Cancer Genetics Program, National Cancer Institute-Frederick, NIH, Frederick, Maryland

• 2012-2013; Guest lecturer, Department of Biotechnology, University of Burdwan, Burdwan, West Bengal, India

TEACHING and MENTORING EXPERIENCE:

• 2022-2022; Aaron Rice, UT Medical Student, Effect of n3-PUFA on retinal degeneration.

• 2021-2022; Bradley Hambly, UT Medical Student, Effect of sphingosine -1-phosphate inhibition on corneal wound healing process.

• 2021-2022; Richard Grambergs, UT Medical Student, Effect of n3-PUFA on corneal wound healing.

• 2020- present; Faiza Tahia, Graduate student, College of Pharmacy, Evaluation of sphingolipid biosynthetic inhibitor SPT-I in prevention of retinal degeneration

• 2020; Aram Bejnood, UT Medical Student for summer, Evaluation of sphingolipid biosynthetic inhibitor SPT-I in prevention of retinal degeneration

• 2016-2018; Srikant Basu, Visiting Fellow, Mouse Cancer Genetics Program, NCI-Frederick, Role of perinuclear signaling complex in transmission of oncogenic signals

• 2015; Swetha N, Summer student, Mouse Cancer Genetics Program, NCI-Frederick, Role of AMP activated kinase (AMPK) alpha subunit in proliferation of cancer cells

• Summer 2015; Introduction to safe laboratory techniques, NCI-Frederick, 2 credit hours, 15-20 Summer students

• 2012-2013; Introduction to Molecular Biology, Department of Biotechnology, University of Burdwan, Burdwan, West Bengal, India, 3 credit hours, 20-25 students; Lecturer – Structure and replication of DNA and RNA

• 2012-2013; Introduction to Molecular Biology, Department of Biotechnology, University of Burdwan, Burdwan, West Bengal, India, 3 credit hours, 20-25 students; Lecturer – prokaryotic transcription and translation

EDITORIAL APPOINTMENTS:

• 2017- present; Journal of Biomedical Sciences, Insight Medical Publishing, Editorial Board Member

• 2016- present; Journal of Bioengineering and Biomedical Science, Hilaris Publishing SRL, Editorial Board Member

• 2016-2021; Biology and Medicine, Walsh Medical Media, Editorial Board Member

•    2017; BioMed Research International, Hindawi Publications, Guest Editor for the Special Issue: Structural Biology

COMMITTEES AND OFFICES HELD:

• 2021- present; UT Promise Undergraduate Scholarship Program Mentor

• 2020- present; UTHSC Hamilton Eye Institute Culture Committee
   
• 2019- present; UTHSC Hamilton Eye Institute Vision Research Seminar Series Co-organizer

• 2022- present; Reviewer, International Journal of Molecular Sciences, MDPI

• 2022- present; Reviewer, Cells, MDPI

• 2022- present; Reviewer, Experimental Eye Research, Elsevier Publications

• 2021- present; Reviewer, Archives of Clinical Ophthalmology, Scientific Archives

• 2020; Scientific Judge, Post-doctoral Research Day, UTHSC

• 2015- present; Reviewer, Cancer Letters, Elsevier Publications

• 2015- present; Reviewer, Peer J, Peer J Publishing

• 2014- present; Reviewer, PLoS One, PLOS Publishing

• 2014-2017; Scientific Judge, Spring Research Festival, NCI-Frederick

• 2015-2016; Steering Committee Member, NIH Center for Cancer Research-Fellows and Young Investigator (CCR-FYI) Colloquium

RESEARCH SUPPORT:

• 07/2021-06/2023; Career Starter Research Grant in Pedeatric Ophthalmology, Knights Templar Eye Foundation, Role: Principle investigator, Project Title: A Novel Anti-Ceramide Gene Therapy for Retinitis Pigmentosa; Support total: $70,000

BOOK CHAPTERS:

• Basu SK and Mandal N. Image Based Longitudinal Characterization of Corneal Wound to Understand the Role of Sphingosine-1-phosphate. Methods in Molecular Biology: Lipidomics, Springer-Nature, London, 2022 (In press)

• Wilkerson JL, Basu SK and Mandal N. Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. Methods in Molecular Biology: Lipidomics, Springer-Nature, London, 2022 (In press)

• Basu SK, Ganguly N, Mir FA, and Sharma P. A mycobacterial secretory protein, MTSA-10, modulates phosphorylation of several macrophage signaling proteins. In: Sharma P. edited, Tuberculosis: Current Research Trends. New Delhi: Allied Publishers Pvt. Ltd. p. 189-198, 2004.

• Ganguly N, Basu SK, Mir FA, and Sharma P. Role of 6-kDa early secretory antigenic target (ESAT-6), a leading tuberculosis vaccine candidate, in the “deactivation” of the macrophages. In: Sharma P. edited, Tuberculosis: Current Research Trends. New Delhi: Allied Publishers Pvt. Ltd. p. 174-188, 2004.

PEER-REVIEWED JOURNAL ARTICLES:

(Total Citations: 737; h-index: 10; i10-index: 10; Source: Google Scholar)

1. Nicholas SE, Barrientez B, Lam TN, Basu SK, Mandal N and Karamichos D. Elucidation of Sphingolipid and TGF-β signaling in the human corneal stroma (Submitted Dec 2022 in Experimental Eye Research).

2. Wilkerson JL*, Basu SK*, Stiles MA, Grambergs RC, Prislovsky A, Nicholas S, Karamichos D, Allegood JC, Proia RL, and Mandal N. Ablation of sphingosine kinase 1 protects cornea from neovascularization in a mouse corneal injury model. Cells Sept; 11(18): 2914, doi: 10.3390/cells11182914, 2022 (* Equal Contribution). Citations: 0; Impact Factor: 7.66

3. Mondal K*, Porter H*, Cole II J*, Pandya HK*, Basu SK*, Khanam S, Chiu CY, Shah V, Stephenson DJ, Chalfant CE and Mandal N. Hydroxychloroquine causes early inner retinal toxicity and affects autophagosome-lysosomal pathway and sphingolipid metabolism in the retina. Mol Neurobiol. Jun; 59(6):3873-3887, doi: 10.1007/s12035-022-02825-3, 2022 (* Equal Contribution). Citations: 2; Impact Factor: 5.59

4. Simon MV*, Basu SK*, Qaladize B, Grambergs R, Rotstein NP, Mandal N. Sphingolipids as critical players in retinal physiology and pathology. J Lipid Res. Feb 6; 62:100037, doi: 10.1194/jlr.TR120000972, 2021 (*Equal Contribution). Citations: 23; Impact Factor: 6.67

5. Mandal N*, Grambergs R*, Mondal K*, Basu SK*, Tahia F*, Dagogo-Jack S. Role of ceramides in the pathogenesis of diabetes mellitus and its complications. J Diabetes Complications Feb; 35(2):107734, doi: 10.1016/j.jdiacomp.2020.107734, 2021 (* Equal Contribution). Citations: 24; Impact Factor: 3.22

6. Basu SK, Basu S and Johnson PF. Localized RAS signaling drives cancer. Oncoscience 6(3-4):298-300, 2019. Citations: 2; Impact Factor: 1.42

7. Basu SK*, Gonit M*, Salotti J, Chen J, Bhat A, Gorospe M, Viollet B, Claffey KP and Johnson PF. A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3′UTR mechanism. Oncogene 37(26):3528-3548, 2018 (*Equal Contribution). Citations: 11; Impact Factor: 9.87

8. Basu SK, Lee S, Salotti J, Basu S, Sakchaisri K, Xiao Z, Walia V, Westlake CJ, Morrison DK and Johnson PF. Oncogenic RAS-induced perinuclear signaling complexes requiring KSR1 regulate signal transmission to downstream targets. Cancer Research 78(4):891-908, 2018 (Cover Article). Citations: 17; Impact Factor: 13.31

9. Kim KM, Noh JH, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K and Gorospe M. Identification of senescent cell surface targetable protein DPP4. Genes & Development 31(15):1529-1534, 2017. Citations: 148; Impact Factor: 12.89

10. Basu SK, Malik R, Huggins CJ, Lee S, Sebastian T, Sakchaisri K, Quiñones OA, Alvord WG and Johnson PF. 3'UTR elements inhibit Ras-induced C/EBPβ activation and senescence in tumor cells. EMBO J. 30(18):3714-28, 2011. Citations: 50; Impact Factor: 14.2

11. Basu SK, Kumar D, Ganguly N, Rao KVS and Sharma P. Mycobacterium tuberculosis Secreted Antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases. Ind. J. Exp. Biol. 47(6): 505-19, 2009. Citations: 8; Impact Factor: 0.94

12. Ganguly N, Gupta C, Giang PH, Basu SK, Siddiqui I, Salunke DM and Sharma P. Mycobacterium tuberculosis secretory proteins CFP-10, ESAT-6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-kappaB transactivation by downregulation of reactive oxidative species (ROS) production. Immunol. Cell Biol. 86(1): 98-106, 2008. Citations: 124; Impact Factor: 5.85

13. Ganguly N, Giang PH, Basu SK, Mir FA, Siddiqui I, and Sharma P. Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. BMC Immunol. 8: 24, 2007. Citations: 63; Impact Factor: 3.86

14. Basu SK, Kumar D, Singh DK, Ganguly N, Siddiqui Z, Rao KVS and Sharma P. Mycobacterium tuberculosis secreted antigen (MTSA-10) modulates macrophage function by redox regulation of phosphatases. FEBS J. 273: 5517-5534, 2006. Citations: 26; Impact Factor: 5.54

15. Singh DK, Kumar D, Siddiqui Z, Basu SK, Kumar V and Rao KVS. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121: 281-293, 2005. Citations: 239; Impact Factor: 66.85

RECENT PRESENTATIONS:

• Basu SK, Cole II J, Qaladize B, Mondal K, Zhi K, Raji B, Kochat H, Brown K and Mandal N. A Novel Topical Formulation of FTY720 Protects Photoreceptors in Animal Model of Light Induced Retinal Degeneration. Association for Research in Vision and Ophthalmology (ARVO); Virtual Meeting, 2021 (Poster)

• Cole II J, Mondal K, Basu SK, Qaladize B and Mandal N. Reduction of Cellular Ceramide Levels Prevents Photoreceptors Degeneration in Rd10 mice. Association for Ocular Pharmacology and Therapeutics (AOPT); Miami, FL Virtual Meeting, 2021 (Poster)

• Cole II J, Khanam S, Mondal K, Basu SK, Zhi K, Kochat H, Brown K and Mandal N. Sphingolipid Modulators as Retinitis Pigmentosa Therapeutics. Association for Research in Vision and Ophthalmology (ARVO), Baltimore, MD, 2020 (Poster)

• Mondal K, Cole II J, Basu SK, and Mandal N. Hydroxycholoroquine effects retinal functions by regulating sphingolipid metabolism. Association for Research in Vision and Ophthalmology (ARVO), Baltimore, MD, 2020 (Poster)

• Basu S, Basu SK, Salotti J, Johnson PF. Role of Rab GTPases and endosomal adaptor proteins in oncogenic RAS induced formation of perinuclear signaling complexes (PSCs). American Association for Cancer Research (AACR) Annual Meeting, Chicago, IL 2018 (Poster)

• Basu SK, Lee S, Sakchaisri K, Walia V, Westlake CJ, Morrison DK and Johnson PF. Oncogenic Ras signaling involves formation of perinuclear CK2 alpha and p-ERK1/2 signaling complexes that require the KSR-1 scaffold protein and endosomal trafficking. American Association for Cancer Research (AACR) Frontiers in Basic Cancer Research, Philadelphia, PA 2015 (Poster)

• Lee S, Basu SK, Walia V, Morrison DK, and Johnson PF. Oncogenic Ras signaling involves sustained perinuclear localization of the effector kinases p-ERK1/2 and CK2 via KSR-1 and endosomal trafficking.  American Association for Cancer Research (AACR) Special Conference on RAS Oncogenes: From Biology to Therapy, Lake Buena Vista, FL 2014 (Poster)

• Basu SK, Malik R, Huggins C, Lee S, Sebastian T, Sakchaisri K, Quinones O, Alvord G and Johnson PF. Functional regulation of the transcription factor C/EBPβ by its 3′UTR. American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, Washington DC 2011 (Poster)

• Basu SK, Malik R, Huggins C, Lee S, Sebastian T, Sakchaisri K, Quinones O, Alvord G and Johnson PF. 3′UTR regulates the function of the transcription factor C/EBPβ. Center for Cancer Research Fellows and Young Investigator (CCR-FYI) Colloquium 2010 (Oral presentation)